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PMID: 11391574

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Employee contributions: $24,500 up $1,000 from 2025 Catch-up contributions (age 50+): $8,000 up $500 from 2025 Catch-up contributions (ages 60 to 63): $11,250 no change from 2025 These limits apply per person , across all 401(k) plans you participate in

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Its levels decrease as a result of aging, stress and exposure to toxins