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Fabry nephropathy results from the accumulation of Gb3 in renal cells, including podocytes, glomerular endothelial cells, mesangial cells, tubular epithelial cells, and vascular endothelial cells 6,7
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Moreover, the use of GST 4QN as a tag reduced fused p53 aggregation and enhanced the induction of p21 transcription and apoptosis in cells treated with 5-fluorouracil (5-FU)
It shares a high degree of sequence homology with desnutrin, including positioning of the G X S X G and DGG active site motifs (9)
In addition, since its discovery, bromelain demonstrated interesting pharmacological and potential medical applications