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Kidney function biomarkers, including creatinine clearance and urea levels, shift towards younger reference values, indicating the restoration of tissue homeostasis

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For instance, microfluidic-fabricated composite NPs co-loaded with a GLP-1 analogue and sitagliptin reduced fasting glucose levels 1.7-fold more effectively than either agent alone in db / db mice, with sustained HbA1c reductions over six weeks [420]

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