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Statistically, up to 70% of dogs with mild MR will likely never go into heart failure, while dogs with severe MR will almost certainly go into heart failure

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Energy improvements from GLP-1 therapy typically develop gradually over weeks to months as blood glucose stabilises and weight loss occurs, rather than immediately

Then, a 10 min recording with excitation was started, and after establishment of a baseline consisting of 10 frame pairs, NMDA (50 M, Tocris) + GLP-1 or GLP-1MK-801 was bath-applied