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Considering the absence of a clear NLS (nuclear localization signal), this nuclear localization is more likely due to a passive diffusion through nuclear pore rather than to a specific targeting

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It was found that the expression of GCH1 triggers the production of potent antioxidants BH4/BH2, which can block lipid peroxidation and ferroptosis, whether supplemented exogenously or produced endogenously

G.ObradovicZ.et al (2004)

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