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An example was presented by Grant et al., [162] with romidepsin that is activated by intracellular GSH by cleavage of a disulfide bond

It also promotes synthesis of elastin, glycosaminoglycans, and other matrix components that give tissues their characteristic properties

Recent work has translated these principles into several families of multifunctional nanoplatforms with distinct TME-focused intervention strategies, which are outlined below [48]

Natural Production Limits: Your body continuously produces glutathione, but stress, ageing, and illness deplete stores faster than production replenishes them