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ANSWER: There are many reasons for reactions such as this

NRF2 is a member of the cap n collar (CNC)-bZip transcription factor family that upon recognition of the antioxidant response cis element (ARE) heterodimerizes with small musculoaponeurotic fibrosarcoma (sMAF) proteins to activate transcription (Igarashi et al, 1994

2006 Jul 1;88(7):1448-57

Once ingested, cyanocobalamin must be converted by the body into active formsmethylcobalamin and adenosylcobalaminthrough enzymatic reactions in various cells throughout the body

PE-22-28 promotes neurogenesis and neuronal excitability (functional changes) Cognitive data : Dihexa has been directly tested in cognitive paradigms

Nat Rev Endocrinol 9 , 346356 (2013)