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This research was funded by VtR Inc-CGU (SCRPD1L0221), DOXABIO-CGU (SCRPD1K0131), and a CGU grant (UZRPD1L0011, UZRPD1M0081)

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The same release kinetics and metabolite in cells were shown with and without the cleavable sequence

Altogether, these proinflammatory changes in vascular homeostasis are known to promote proatherogenic accumulation of both inflammatory leukocytes and LDL in the vascular wall 36 (Fig

Interestingly, 7 days of relatively low Mn exposure reduced TH-expressing cells in neuron-glial cultures, not in neuron cultures alone, indicating glial cells may exacerbate Mn toxicity in neurons (Zhang et al., 2010)