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Altered expression of glutamate transporters, including the cystineglutamate transporter (xCT) system, increases concentrations of extracellular glutamate, which contribute to epileptic discharge, tumour proliferation and peripheral excitotoxicity

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Research on berberine in isolation does not validate a multi-ingredient blend that happens to contain some berberine

Common side effects include increased appetite (from the higher metabolism) and potential sleep issues if taken too late in the day