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Acknowledgments The authors thank the: (i) Department of Chemistry and Department Biology at the University of Massachusetts (UMASS), (ii) Lung Cancer Research Foundation, (iii) Institute for Applied Life Sciences/Collaborative Cancer Research Grant at UMASS for financial support

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Values presented as percentage of total Adverse events are presented for all participants who were randomised and took at least one dose of treatment, regardless of whether they discontinued * For the T2D trial, this was limited to supraventricular arrhythmias and cardiac conduction disorders ** For the obesity trial these are presented as hepatic disorder / biliary disorder separately NA : Not applicable In the obesity trial, serious adverse events (SAEs) occurred in 4% of participants with retatrutide use overall (06% across groups) vs