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Gao X, et al

Lastly, the dose is a problem.

Lekamge DN, Lane M, Gilchrist RB, Tremellen KP: Increased gonadotrophin stimulation does not improve IVF outcomes in patients with predicted poor ovarian reserve

It can take many years (approx 20) to develop a deficiency disease in those altering their diet to one lacking in B12 due to reabsorbtion however, if failure to absorb leads to B12 deficiency disease occur within a few years (3-4)

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Nauck MA et al (2011): Rapid tachyphylaxis of the glucagon-like peptide 1-induced deceleration of gastric emptying in humans