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October 2022

However, as insulin sensitivity eventually declines and insulin demand rises, -cells can no longer sustain insulin production, and the patient enters the dysfunctional (decompensated) stage, where hypoinsulinemia, hyperglycemia, and dyslipidemia appear (Hu et al., 2022)

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Infected cells were selected with puromycin (2 g/mL) for 710 days to establish stable knockdown cell lines