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doi: 10.1146/annurev-cellbio-100913-013325 154 ItohN.ItohY.TassoniA.RenE.KaitoM.OhnoA.et al

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These findings align with global analyses from Europe, North America, and Asia reporting similar population-level increases in vitamin B12 deficiency, where prevalence ranges from 5 to 20% depending on age, diet, and socioeconomic status

MAPK pathways activate and phosphorylate downstream proteins (Guo et al

These observations underscore the complexity of oxidative stress regulation in Down syndrome and suggest that the relationship between NRF2 and downstream targets may be context-dependent, particularly during fetal development

LePHGPX thus acted as cytoprotector in plants under different local stress conditions ( PHGPX genes in animal organisms ( GPX4 / PHGPX genes in plants may be involved in defense against cell death induced by pathogens