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Effects of peripheral or central GLP-1 receptor blockade on leptin-induced suppression of appetite

Ludvigsson JF, Ludvigsson J, Ekbom A, Montgomery SM

The guides on drinking alcohol while on semaglutide and alcohol use with tirzepatide address both safety and the impact on weight loss outcomes

These findingsoriginating from landmark trials such as EMPA-REG OUTCOME, LEADER, and SUSTAIN-6have led to substantial revisions in international guidelines from the European Society of Cardiology, American College of Cardiology, and American Heart Association, which now recommend the use of SGLT2i or GLP-1 RAs, often in conjunction with metformin

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Mallinson D, Mullen AB, Lamprou DA