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Semaglutide (Wegovy 2.4 mg) The STEP trials , which evaluated semaglutide for weight loss, found that patients taking 2.4 mg of semaglutide weekly achieved an average weight loss of 14.9% of their body weight over 68 weeks

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Variation in MC4R , a melanocortin receptor central to satiety, together with FTO , GLP1R (the receptor these compounds target), and TCF7L2 (linked to glucose regulation), outlines your baseline metabolic terrain

The study did not qualify for prospective registration as a clinical trial because there was no study directed intervention

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Ultimately, who is a good candidate for GLP-1 will depend on the specific inclusion and exclusion criteria of each trialbut in general, those struggling with weight-related health conditions and willing to engage in medical research are strong candidates