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By comparison, Mounjaros pivotal SURMOUNT-1 trial reported up to around 22.5% mean weight loss at 72 weeks, and Wegovys STEP-1 trial reported around 14.9% at 68 weeks

However, as millions of people begin GLP-1 therapy, questions about less common side effectsincluding musculoskeletal painhave surfaced

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Nutritional support also matters: ensuring adequate protein and healthy fat intake helps sustain metabolic rate during weight loss, reducing how dramatically your body temperature may drop

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