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Zonisamide suppresses endoplasmic reticulum stress-induced neuronal cell damage in vitro and in vivo
Miss one, and the timeline compresses to days instead of weeks
The fact that GSH production is required during conditions that cause overproduction of ERgenerated ROS suggests a role for GSH in their elimination
GSH and pyroptosis Pyroptosis is a form of lytic cell death characterized by gasdermin-mediated plasma membrane pore formation, leading to osmotic swelling, membrane rupture, and the release of mature pro-inflammatory cytokines, including interleukin 1 beta (IL1B, also known as IL-1) and interleukin 18 (IL18)