It has been available longer than tirzepatide, which means more post-market surveillance data exists for patients with thyroid conditions
However, clinical studies have not demonstrated clinically significant differences in half-life based on body mass index (BMI) alone
In contrast, Noom states that their dosing starts at 25% or less of the standard 0.25 mg dose and escalates at a personalized rate. While microdosing GLP-1 medications may provide a more personalized experience, there are still questions regarding the safety of this practice as there are currently no published studies on the process, and the microdoses may come from a compounding pharmacy
PMID 20854877
Project IDs 322900939 (M03, M05) (to NM), GRK2816 and BI1292/12-1 (to ALB), 520275106 (to the Emmy Noether Research Group), and SFB TRR 219 - 322900939 - M-07 (to FK)
The influx of calcium then activates proteases that cleave proglucagon peptides, ultimately boosting GLP-1 production