Your gastric emptying (the speed at which your stomach releases food into your small intestine) also slows down, meaning food stays in your stomach longer and you feel satisfied on smaller portions
Excess vitamin B12 is linked to increased cancer growth in certain types of cancer.[ref] Methotrexate, a chemotherapy drug, works by inhibiting the production of methyl folate, thus limiting methionine and DNA synthesis for cell growth
In trials, overall GI events rose with higher doses and faster escalations
Too much too soon can lead to side effects like fatigue, blood sugar crashes, or unwanted water retention
Semaglutide medications work by activating the GLP-1 receptor alone, while tirzepatide medications activate both the GLP-1 receptor and the glucose-dependent insulinotropic polypeptide (GIP) receptor, creating what is commonly described as a dual incretin mechanism
The additive cardiovascular strain from both medications could precipitate another event in someone whose cardiovascular system has already demonstrated vulnerability
