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These results suggest that the localization of layer2/3 specific hyper-glutamatergic signaling in the PFC of these mice, presumably due to receiving projections from the thalamus, shows construct validity, such as the anatomical features observed in patients with ASD

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These studies provided important insights, however, one limitation of these investigations is the fact that there were very few participants in each of these studies (between 38 participants) 4,6,16,19,20 , thus making deductions on a population level incomplete and uncertain