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The discovery of the second incretin, GLP-1, originated from observations in 1982 that anglerfish proglucagon mRNA contained coding sequences of glucagon-related peptide, flanked by pairs of basic amino acids characteristic of the sites cleaved during post-translational processing of prohormones (19)

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5.4 Patient management considerations In clinical practice, selecting the appropriate pharmacotherapy for patients with CRHM syndrome requires an individualized, patient-centered approach

In some in-vitro studies, fibroblast cultures exposed to AHK-Cu complexes appeared to show an increase in collagen type I production, with reports of increases as high as 300% over controls

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