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Hyperpigmentation occurs when the skin produces excess melaninthe natural pigment responsible for skin, hair, and eye colour

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Conclusions The results of this study indicate that low-dose (0.025 mg/kg) oral rapamycin, administered three times a week for one to five months to healthy, middle-aged large breed dogs, resulted in detectable concentrations of rapamycin in four dogs that was measurable in ng/ml

doi:10.1134/s2079057019030147

1997, Austin, TX: R.G

[2] [3] Among the vertebrates, there exist six different somatostatin genes that have been named SS1, SS2, SS3, SS4, SS5 and SS6