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Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11)

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Its progression is closely linked to the activity and stability of GPX4, making the inhibition of lipid peroxidation and the preservation of GPX4 function pivotal targets in ferroptosis-based therapeutic interventions

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Additionally, vitamin C can mitigate the adverse effects of oxidative stress, protecting against damage to the liver and kidneys

10.1016/j.mito.2010.03.001 Mitochondrion 144 SaitoY.MiyasakaT.HatsutaH.Takahashi-NikiK.HayashiK.MitaY.et al (2014)