Some of the negative effects of high homocysteine levels are modulated by the PON1 genotype.[ref] BLMH and BPHL are additional enzymes that can also metabolize homocysteine-thiolactone.[ref] Higher levels of homocysteine-thiolactone are also found in chronic inflammatory conditions, such as rheumatoid arthritis, inflammatory eye disease, and AMD.[ref][ref][ref] Lets take a look at why high homocysteine levels cause problems in the body, and then well look at genetic variants in the above cycles that can affect homocysteine levels when combined with dietary choices
coli MG1655 and its mutants were incubated with 10 mM GSH at 37 C for 2 h
PMID: 29688261 Bahri Khomami M, et al
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Despite its potential, curcumins clinical applications are limited by poor water solubility, rapid metabolism, and low systemic bioavailability (Liu et al., 2013)
(36988597) clinical clues suggesting epileptic seizure epileptic seizure Emesis
