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Probiotic-derived EPS activate TLR2 on DCs, fostering a tolerogenic phenotype characterized by IL-10 secretion and reduced autoreactive B/T cell activation (108, 146)

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An overview of clinical and preclinical studies investigating microbiota-based interventions in T1D and T2D is summarized in Table 2 and 3, which highlights the diversity of approaches, ranging from probiotic supplementation and FMT to engineered bacterial strains

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Altogether, these results suggest that mitochondria-related metabolic pathways in innate immune cell populations are altered in patients with pSS

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