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Before human translation, essential parameters to define: optimal dosing, infusion/administration route, frequency, biomarkers to monitor (senescent cell burden, inflammatory cytokines, organ function), long-term follow-up for adverse outcomes (especially tumour risk)

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One receptor-binding nuance deserves attention: whether KPV binds to melanocortin receptors and uses identical signaling pathways as its parent peptide alpha-MSH is not yet fully clear

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Follow laboratory handling protocols