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[12] [15] Sickle-cell crisis (vaso-occlusive crisis) requiring hospitalization has been reported in patients treated with sildenafil for pulmonary hypertension secondary to sickle cell disease

Key adjustments at this phase: Reduce portion sizes by 20% to 30% across all meals Add a sixth small meal if you cannot finish larger ones Move heavy carbohydrates to earlier in the day when digestion is strongest Switch to softer, easier-to-digest proteins (fish, eggs, Greek yogurt) on dose increase days Keep hydration consistent at 8 to 10 glasses per day, sipped throughout rather than gulped at meals Phase 3: therapeutic doses (10mg, 12.5mg, 15mg, weeks 13+) At higher doses, some people find eating enough to be the challenge, not eating too little

MHRA GLP-1 Medicines: What You Need to Know (GOV.UK, 2026) The content on the SheMed blog is provided for general informational and educational purposes only

This supplement is designed to work alongside your program to support gut health and maintain your momentum

This represents clinically significant improvement associated with reduced cardiovascular risk, improved glycemic control in those with diabetes, and decreased joint stress

Nat Rev Endocrinol 14(2):8898