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Methylcobalamin is the active coenzyme form of B12, while cyanocobalamin is a synthetic form requiring conversion in the liver

L-Carnitine

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Other factors like competition from other amino acids, reduced uptake by cationic amino acid transporters (CATs), and elevated arginase activitycommon in conditions such as hypertension and diabetescan limit L-arginine availability to eNOS, diverting it away from NO production (McDonald et al., 1997a