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Despite the promise of the biologic and kinase-inhibitor approaches, which are currently represented in clinical trials, both have limitations arising from toxicity or specificity considerations and/or cost

Peer review Peer review information Nature Reviews Molecular Cell Biology thanks Charles Brenner, Evandro Fang and Lindsay Wu for their contribution to the peer review of this work

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Genitourinary There is growing evidence that ketamine can cause urologic complications, although this is primarily from animal studies and chronic recreational use by humans

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