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Revascularization is an effective strategy for salvaging ischemic myocardium in myocardial infarction [194, 195], while restoration of blood flow to the ischemic myocardium paradoxically exacerbates cardiac tissue damage, a phenomenon known as myocardial ischemiareperfusion (I/R) injury [196, 197]

No published human trials

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However, the basis for the increased lactate and pyruvate, in some instances, may relate to non-mitochondrial processes such as glycolysis as is suggested by the absence of increased alanine and TCA intermediates noted in some other biomarker clusters (Figure 5, group 4)

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A high toxic burden : Our bodies are designed to process and eliminate any toxins we come into contact with through our natural detoxification pathways