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This is a crucial metabolic process that regulates hormone and DNA synthesis, second to none in the importance that B12 plays in our system's metabolism and immunity functions

Notably, elevated adiposity further reduces serum IGF-I concentrations independent of chronological age

doi: 10.1177/11786469241232871 108 GulcevMReillyCGriffinTJBroecklingCDSandriBJWitthuhnBAet al

In this context, ferroptosis has garnered increasing attention as a promising target for early diagnostic strategies, given that iron accumulation in the SN is a characteristic feature of PD

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Intracellularly, iron accumulation inhibits antioxidant systems