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Calle, R

However, TNF is likely to remain the preferred target of first-line biologic therapy for the foreseeable future as, in populations with active RA despite ongoing, nonbiologic, DMARD therapy, biologic inhibition of either IL-6 or IL-1 demonstrates no obviously superior outcomes to TNF blockade

A CobaSorb test showing a clear increase in holoTC supports a normal uptake, while an increase below a set limit should be taken with some reservation before a conclusion of a permanent impaired uptake of B12 is made