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GLP-1 receptor agonists in PD Approved treatments for PD target dopaminergic neurotransmission, with levodopa representing the mainstay of treatments augmenting dopamine production and alleviating motor symptoms [6]

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This is particularly relevant with retatrutide, where the pace of weight loss is faster and the risk of excessive lean mass loss is proportionally higher, though the glucagon component may offer some muscle-sparing benefit

First, an amino acid substitution stops DPP-4 from destroying GLP-1

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It does not tell your body what to do with the resulting deficit