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Mechanistically, a 2026 PubMed review points to angiogenesis, collagen synthesis, fibroblast activity, and nitric oxide modulation as the likely pathways

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The TRANSCEND-T2D-1 trial (NCT06354660) demonstrated HbA1c reductions of 1.7-2.0% and 36.6 lbs mean weight loss in type 2 diabetes participants over 40 weeks

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