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Aconitate hydratase isozymes: subcellular location, tissue distribution and possible subunit structure

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[DOI] [PubMed] [Google Scholar] 259.Kuhla A., Derbenev M., Shih H.Y., Vollmar B

Although biochemically separated from the GSH system, the Trx system shares NADPH as a common reducing cofactor and serves as an alternative pathway for reducing disulfide bonds, making this system especially relevant if the GSH system has been compromised or rendered dysfunctional ( Under oxidative stress these three systems work in concert to detoxify ROS and lipid peroxides, maintain protein structure and function via thiol repair, prevent activation of redox-sensitive inflammatory pathways, and preserve mitochondrial membrane integrity and prevent apoptosis