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After oral administration of L-theanine, the metabolic activity of brown fat and subcutaneous white fat were increased, which significantly improved the obesity and hepatic steatosis of mice fed a high-fat diet (HFD), and the composition of intestinal microflora was also reasonably regulated (81)

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Testing of the metabolites and analogs indicated that curcumin was the major naturally occurring activator of GPR55 and that both the methoxy group and the heptadienone moiety of curcumin were required for the maximal effects