Non-senescent cells do not rely on this interaction, so they are not affected
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MTHFR in Psychiatry Group de Hert M, Delespaul P, van Winkel R, Rutten BP
Here is the important part: every gram of glycogen binds approximately 3 grams of water
This is due to them being often bland, easily digestible, and they provide quick energy from the carbohydrates
Cramb K, Beccano-Kelly D, Cragg SJ, et al