glp-1 cirrhosis GI and Hepatology News Multiple target tissue effects of

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Many patients notice reduced appetite within weeks, with steady weight loss over time

The extensive role of GLP-1Rs and their agonists in other organs and tissues are shown in the overview in Fig

While additional research is required, IGF-1 LR3 may help understand the molecular underpinnings of metabolic function in various cellular systems

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Extended-duration effects of GLP-1 RAs and multi-agonists on liver-associated outcomes involving cirrhosis development, HCC incidence, and death from hepatic causes are being elucidated through ongoing observational studies and long-term trial extensions [65-70]