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Methylation of cytosine at DMRs inhibits the process that pertains to the binding of transcription factors to the locations that are considered regulatory towards the relevant genes, verging on silencing or transcriptional inactivation

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Among them, GPX1-4 and 6 are selenocysteine-containing proteins

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This triggers the MAPK cascade, such that Ras-GTP activates Raf [also called MAPK kinase kinase (MAPKKK)], which in turn activates MEK1/2 [MAPK kinase (MAPKK)]

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