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Functions, pathophysiology and current insights of exosomal endocrinology (review)

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ECM : Extracellular Matrix

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Interventions such as the antioxidant NAC or the inhibition of MAPK8/JNK activity have been demonstrated to mitigate ROS-induced parthanatos in glioma cells [156], suggesting that MAPK8 activation contributes to parthanatos by enhancing intracellular ROS levels