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The concordance between these retrospective clinical findings and our experimental data provides supportive evidence for a potential preventive and therapeutic role of metformin in human OA progression

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Cell death and subsequent HMGB1::Lucia release induced by RSL3, a strong ferroptosis inducer, can be blocked by Ferrostatin-1, a potent ferroptosis inhibitor

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But all this incredible potential is governed by one formidable limitation: the GHK-Cu half life