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Over time, this leads to consistently higher drug levels, more side effects, and a pattern that can mimic overdosing

TRIUMPH-1 (NCT05929066) will look at the efficacy and safety of retatrutide in people with overweight/obesity without T2D and will include subsets of participants with knee osteoarthritis (OA) or OSA

Marshall CR, Howrigan DP, Merico D, Thiruvahindrapuram B, Wu W, Greer DS, et al

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This makes the 8mg/mL concentration impractical for patients who have titrated past the 7.5mg dose level