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En ocasiones pueden tener un borde irregular y puede haber un historial de cambio de color que puede causar confusin con otros pigmentado lesiones, incluidas melanoma

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Jang YP, Zhou J, Nakanishi K, Sparrow JR

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Studies have found that this difference in susceptibility is caused by higher expression of the INS gene and proinsulin protein in the thymus and lower expression in the pancreas of human patients harboring the class III allele compared to class I expression