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Thus, in situ produced microbial folate may favourably influence the cellular nutrition of the local colonocytes and may be important in maintaining intestinal homeostasis and modulating gut microbiome function, e.g., through regulation of colon mucosal proliferation (i.e., colorectal cancer prevention) and its anti-inflammatory effects 248,249,256,257,277,278,279,280,281,282,283,284,285,286

Despite the high cost and potential downsides, Ozempic skyrocketed in popularity last year, with 66% of its more than $13 billion sales coming from the US, according to Novo Nordisks 2023 annual report