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74 In a comparative study in obese male mice of vertical sleeve gastrectomy (VSG), semaglutide treatment, and controls, both interventions improved glycemic control and reduced body weight, but VSG significantly decreased energy expenditure and induced notable bone loss, whereas semaglutide preserved BMD over six weeks

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But these health issues may raise your risk: Diabetes High blood pressure High cholesterol Obstructive sleep apnea Taking certain medications (PDE4 inhibitors) Smoking Eye problems that can increase your risk include: Previous NAION in one eye A naturally crowded optic nerve (called disk at risk) Having prior eye surgery You can still take semaglutide or other GLP-1 drugs if you have these conditions

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