Use of the arginine-depleting agent pegylated arginine deiminase ADI-PEG20 in GBM can increase nitric oxide (NO) synthesis and produce cytotoxic pernitrite, increasing the sensitivity of tumor cells to ionizing radiation and significantly enhancing the effect of radiotherapy on GBM
[DOI] [PMC free article] [PubMed] [Google Scholar] 182.Shuto Y, Shibasaki T, Otagiri A, et al
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Why Melasma Requires a Different Strategy Melasma is not simply dark spots. It is a hormone-influenced, inflammation-driven condition in which melanocytes (pigment-producing cells) become overstimulated