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It will depend on the ability to connect multiple sources of evidence, including: Clinical trial data Real-world clinical data Patient-reported outcomes Biomarker and genomic information Healthcare utilization data Digital health technologies The goal is not to replace randomized clinical trials but to complement them, creating a more complete picture of how therapies perform in real-world healthcare settings
However, Ultherapy does offer 1 deeper treatment function that targets the SMAS at 4mm, which no other treatment currently offers (these deep treatment is also why Ultherapy can be very painful)
But the reason providers are increasingly prescribing them together is because they work on different but complementary repair systems, and they do not interfere with each other
The EMPA-REG and CANVAS trials showed that the SGLT-2i empagliflozin and SGLT-1/2i canagliflozin reduced the risk of MACE in T2D patients with or at high risk of CVD by 14%, while the SGLT-2i dapagliflozin did not significantly reduce the risk of MACE, possibly due to the difference in population (approximately 60% with no established ASCVD) between previous trials and strict exclusion criteria
no serious adverse effects in that group
J., Van Nuijs, A
