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In response to stress, an intricate molecular mechanism facilitated by sensor cysteines within Keap1 allows Nrf2 to escape ubiquitination, accumulate within the cell, and translocate to the nucleus, where it can promote its antioxidant transcription program

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In fact, this type of injury can be graded on a scale of severity, from 1 to 4

Continuing for two weeks beyond apparent full recovery helps ensure tissue has truly healed rather than just reaching a temporarily improved but fragile state