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In addition, studies also demonstrated that the C677T polymorphism of MTHFR is associated with onset age of schizophrenia in a dose-dependent manner, such as increasing numbers of the mutant T allele is linked with early onset 50

Br J Clin Pharmacol 56:635638

Renal Impairment : For those with kidney issues, B12 is generally safe because it is water-soluble, but monitoring is required

Estimated dosage per spray: 1 spray 133mcg 2 sprays 266mcg 4 sprays 532mcg 8 sprays 1064mcg Because nasal absorption is generally lower than injectable administration, higher overall usage amounts are commonly discussed compared with subcutaneous use

doi: 10.1111/dom.12973 24