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A sub-study of the randomized phase 3 SURPASS-3 trial evaluated the changes in liver fat content (LFC), abdominal subcutaneous adipose tissue (ASAT), and volume of visceral adipose tissue (VAT) in patients treated with tirzepatide compared to patients treated with insulin degludec

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The initial analysis revealed there is considerable uncertainty about the payback from the weight loss from GLP-1s

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However, GLP-1 RAs are also associated with emerging cutaneous adverse drug reactions, including bullous, exanthematous and vasculitic manifestations, and other rare side effects